The goal of Deep Space Industries is to create an industrial economy that enables the human development of space, by developing the capability to harvest and utilize space resources. However, while its vision for the future is grand, its initial plans involve starting small, by leveraging the capabilities of small spacecraft to prospecting missions to Near Earth Asteroids. This talk will discuss how small, low-cost spacecraft can be used to undertake interplanetary missions, with an emphasis on the plans of Deep Space Industries’ plans, as well as discussing other examples of small, low-cost space exploration missions.